TGF-beta/Smad
PTEN
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Product name : GSK1059615 (GSK-1059615, GSK 1059615)
Product No. : cs-1156
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
GSK1059615 (CAS: 958852-01-1) is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis.
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