TGF-beta/Smad
MNK
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Product name : APS-2-79
Product No. : cs-24444
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
APS 2-79 (CAS: 2002381-25-9 (free base), 2002381-31-7 (HCl salt)) is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site with IC50 values of 120±23 and 418±40 nM for KSR2 and MEK1, respectively. Co-targeting of enzymatic and scaffolding activities within Ras-MAPK signalling complexes is a therapeutic strategy for overcoming Ras-driven cancers.
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