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Products > Others > Others > ML-281 (ML281)
ML-281 (ML281)
Product name : ML-281 (ML281)
Product No. : cs-2166
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 ML-281 (CAS: 1404437-62-2) is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers. 

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