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Products > TGF-beta/Smad > TGF-beta/Smad > SIS-3 (SIS3, SIS3)
SIS-3 (SIS3, SIS3)
Product name : SIS-3 (SIS3, SIS3)
Product No. : cs-2236
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
SMAD3 (CAS: 521984-48-5) is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. 

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