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Products > Apoptosis > Bcl-2 inhibitor > A-1210477 (A1210477)
A-1210477 (A1210477)
Product name : A-1210477 (A1210477)
Product No. : cs-2151
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 A 1210477 (CAS: 1668553-26-1) is an inhibitor of MCL-1 (Ki=0.45 nM in TR-FRET-binding assays), is a much weaker binder of BCL-2 (Ki=0.132 μM) and BCL-XL(Ki>0.660 μM). The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target.

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