TGF-beta/Smad
Phospholipase
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Product name : BVT-273 (BVT2733)
Product No. : cs-2111
Price : 100mg, $475, 500mg/$975
CAS : 376640-41-4)
Bulk inquiry :
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| Details: | ||||||||||||||
BVT 2733 (CAS: 376640-41-4) is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, which attenuates obesity and inflammation in diet-induced obese mice. BVT-2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. BVT-2733 exhibits an anti-inflammatory effect on CIA. This protective effect is, at least partly, mediated by inhibition of the NF-κB and NLRP1 inflammasome signaling pathways. 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) plays an important role in inflammation. 11β-HSD1 inhibition may represent a potential therapeutic target for RA patients.
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