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Products > Protein Tyrosine Kinase/RTK > VEGFR > CP-547632 (CP547632)
CP-547632 (CP547632)
Product name : CP-547632 (CP547632)
Product No. : cs-1957
Price : 100mg, $675, 500mg/$1875
CAS : 
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  Details:
 CP 547632 (CAS: 252003-65-9) is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies. 

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