cckinase, Inc.

Favorite  |  Set Home
E-mail: info@cckinase.com
MI-463 (MI463)
Product name : MI-463 (MI463)
Product No. : cs-1947
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
←[Previous Product]              [Next Product]→
Online Inquiry         Email Us

  Details:
 MI 463 (CAS: 1628317-18-9) is a potent menin-MLL inhibitor with IC50=15.3 nM and Kd=9.9 nM. MI-463 shows its profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia. Pharmacologic inhibition of the menin-MLL interaction represents an effective treatment for MLL leukemias in vivo and provide advanced molecular scaffold for clinical lead identification. Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention. 

  Related Products :

LLY-507 (LLY507)
LLY-507 (LLY507)
Price: 100mg, $475, 500mg/$1275

MI-2 (MI2, MI-2)
MI-2 (MI2, MI-2)
Price: 100mg, $675, 500mg/$1875

BRD-4770 (BRD 4770; BRD-4770)
BRD-4770 (BRD 4770; BRD-4770)
Price: 100mg, $475, 500mg/$1275

MI-503 (MI503)
MI-503 (MI503)
Price: 100mg, $675, 500mg/$1475

C-7280948 (C7280948)
C-7280948 (C7280948)
Price: 500mg, $675

MM102 (MM-102)
MM102 (MM-102)
Price: 100mg, $675, 500mg/$1875

SGC-707 (SGC707)
SGC-707 (SGC707)
Price: 100mg, $475, 500mg/$1275

MI-3 (MI3, MI 3)
MI-3 (MI3, MI 3)
Price: 100mg, $675, 500mg/$1875

Online service

info@cckinase.com