TGF-beta/Smad
EZH2
|
Product name : EPZ004777 (EPZ-004777)
Product No. : cs-1932
Price : 100mg, $675, 500mg/$1875
CAS :
Bulk inquiry :
|
| Details: |
EPZ 004777 (CAS: 1338466-77-5) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells.
|
| Related Products : |
|
|
|
|
||||||||
|
|
|
|
