TGF-beta/Smad
Hippo (MST)
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Product name : Vismodegib (GDC-0449; GDC 0449; GDC0449)
Product No. : cs-1913
Price : 50mg, $675; 100mg, $1175
CAS :
Bulk inquiry :
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| Details: |
Vismodegib (CAS: 879085-55-9) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.
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