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Products > Cell Cycle/DNA Damage > CDK > ML-167 (ML167, CID44968231; CID-4496823)
ML-167 (ML167, CID44968231; CID-4496823)
Product name : ML-167 (ML167, CID44968231; CID-4496823)
Product No. : cs-1892
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 ML167 (CAS: 1285702-20-6) is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (ClkÂ’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (DyrkÂ’s) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome.

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