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Products > Apoptosis > Bcl-2 inhibitor > ABT-263 (Navitoclax, ABT263)
ABT-263 (Navitoclax, ABT263)
Product name : ABT-263 (Navitoclax, ABT263)
Product No. : cs-1871
Price : 500mg, $975
CAS : 
Bulk inquiry : 
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  Details:
 ABT 263 (CAS: 923564-51-6) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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