SB 271046 HCl (CAS: 209481-24-3 (HCl); 209481-20-9 (free base)) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. SB-271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT6 antagonists have been shown to produce nootropic effects in a variety of animal studies. Suggested applications of these drugs include treatment of schizophrenia and other psychiatric disorders.
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