Product name : OTSSP167 (MELK inhibitor; OTSSP-167; OTSSP 167)
Product No. : cs-1832
Price : 100mg, $875, 500mg/$1875
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OTSSP167 (CAS: 1431698-10-0 (OTSSP167 HCl salt); 1431697-89-0 (OTSSP167 free base)) is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). Inhibition of the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells.
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