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Products > Cell Cycle/DNA Damage > Microtubule/Tubulin > ABT-751 (ABT751; ABT 751; E7010; E-7010; E 7010)
ABT-751 (ABT751; ABT 751; E7010; E-7010; E 7010)
Product name : ABT-751 (ABT751; ABT 751; E7010; E-7010; E 7010)
Product No. : cs-1806
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.

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