GDC-0623 (CAS: 1168091-68-6) is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM). MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
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Technical Data
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Appearance:
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Off White Solid
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Purity:
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> 98%
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QC Data:
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 View Current Lot Data File
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CAS:
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1168091-68-6
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Storage
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-20°C, long term; 4°C, short term
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Shipping
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Room temperature
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TGF-beta/Smad
MNK
