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Products > MAPK/ERK Pathway > MEK > GDC-0623 (GDC0623; GDC 0623)
GDC-0623 (GDC0623; GDC 0623)
Product name : GDC-0623 (GDC0623; GDC 0623)
Product No. : cs-1791
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 GDC-0623 (CAS: 1168091-68-6) is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 nM). MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

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