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Products > Others > Others > GSK591 (GSK-591)
GSK591 (GSK-591)
Product name : GSK591 (GSK-591)
Product No. : 201661215239
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
  GSK591 (CAS: 1616391-87-7) is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases. 

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