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FRAX597 (FRAX 597; FRAX-597)
Product name : FRAX597 (FRAX 597; FRAX-597)
Product No. : cs-1774
Price : 50mg, $675; 100mg, $1175
CAS : 
Bulk inquiry : 
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  Details:
 FRAX597 (CAS: 1286739-19-2), a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM). FRAX597 inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. 

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