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Products > Others > Others > LP533401 (LP-533401, LP 533401)
LP533401 (LP-533401, LP 533401)
Product name : LP533401 (LP-533401, LP 533401)
Product No. : cs-1770
Price : 50mg, $675; 100mg, $1175
CAS : 
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  Details:
LP-533401 (CAS: 1040526-12-2) inhibits tryptophan hydroxylase-1 (TPH-1), the first enzyme in gut-derived serotonin biosynthesis. TPH-1 is mostly expressed in peripheral tissues such as the gut, whilst TPH-2 is the major isoform in the central nervous system. Although LP-533401 inhibits human TPH-1 and TPH-2 with similar potency (Ki ~ 0.7µM) in vitro, it selectively lowers serotonin levels in the gut whilst leaving levels in the brain unchanged, likely because the compound does not cross the blood-brain barrier. 

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