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Products > PI3K/Akt/mTOR > PI3K > Acalisib (GS-9820; GS9820; GS 9820; CAL-120; CAL120; CAL 120)
Acalisib (GS-9820; GS9820; GS 9820; CAL-120; CAL120; CAL 120)
Product name : Acalisib (GS-9820; GS9820; GS 9820; CAL-120; CAL120; CAL 120)
Product No. : cs-1758
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 Acalisib (CAS: 870281-34-8) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. It inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells.

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