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Products > PI3K/Akt/mTOR > Akt > Afuresertib (GSK2110183, GSK-2110183, GSK 2110183)
Afuresertib (GSK2110183, GSK-2110183, GSK 2110183)
Product name : Afuresertib (GSK2110183, GSK-2110183, GSK 2110183)
Product No. : cs-1729
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 Afuresertib (CAS: 1047645-82-8 (HCl); 1047644-62-1 (free base)) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

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