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Products > Cell Cycle/DNA Damage > Topoisomerase > FL118 (FL-118, FL 118)
FL118 (FL-118, FL 118)
Product name : FL118 (FL-118, FL 118)
Product No. : cs-1718
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 FL118 (CAS: 151636-76-9) shows structural similarity to irinotecan. However, while the inhibition of DNA topoisomerase 1 activity by FL118 was no better than the active form of irinotecan, SN-38 at 1 µM, FL118 effectively inhibited cancer cell growth at less than nM levels in a p53 status-independent manner. Moreover, FL118 selectively inhibited survivin promoter activity and gene expression also in a p53 status-independent manner. 

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