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Products > JAK/STAT Signaling > EGFR > Irbinitinib (ARRY380; ARRY 380; ARRY-380; ONT380; ONT 380; ONT-380; Tucatinib)
Irbinitinib (ARRY380; ARRY 380; ARRY-380; ONT380; ONT 380; ONT-380; Tucatinib)
Product name : Irbinitinib (ARRY380; ARRY 380; ARRY-380; ONT380; ONT 380; ONT-380; Tucatinib)
Product No. : cs-1710
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 Irbinitinib(CAS: 937263-43-9 (or 937265-83-3)) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.  ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. 

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