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Products > Cell Cycle/DNA Damage > CDK > TG-003 (TG003, TG 003)
TG-003 (TG003, TG 003)
Product name : TG-003 (TG003, TG 003)
Product No. : cs-1704
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
TG003 (CAS: 719277-26-6) is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2(IC50= 200 nM).  TG003 inhibited SF2/ASF-dependent splicing of beta-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. TG003 also suppressed serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells.

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