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NVP-TAE226
Product name : NVP-TAE226
Product No. : cs-1694
Price : 100mg, $475, 500mg/$1275
CAS : 
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  Details:
 NVP-TAE226 (CAS: 761437-28-9) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. AE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration-dependent decrease in cellular proliferation with an associated G(2) cell cycle arrest in every cell line and an increase in apoptosis in a cell-line-specific manner. 

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