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Products > JAK/STAT Signaling > JAK > Decernotinib (VX-509; VX509; VX 509; VRT-831509)
Decernotinib (VX-509; VX509; VX 509; VRT-831509)
Product name : Decernotinib (VX-509; VX509; VX 509; VRT-831509)
Product No. : cs-1650
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 Decernotinib(CAS: 944842-54-0) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. In immune-mediated diseases, JAK3 is an essential component of the immune signaling cascade. This cascade ultimately contributes to abnormal immune response that results in chronic inflammation and, in the case of RA, irreversible damage to cartilage and bones.

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