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Products > Protein Tyrosine Kinase/RTK > FGFR > Debio-1347 (Debio 1347; Debio1347; CH 5183284; CH-5183284)
Debio-1347 (Debio 1347; Debio1347; CH 5183284; CH-5183284)
Product name : Debio-1347 (Debio 1347; Debio1347; CH 5183284; CH-5183284)
Product No. : cs-1637
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 CH5183284 (CAS: 1265229-25-1) is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.

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