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Products > Cell Cycle/DNA Damage > Checkpoint Kinase (ChK) > CCT-244747 (CCT244747, CCT 244747)
CCT-244747 (CCT244747, CCT 244747)
Product name : CCT-244747 (CCT244747, CCT 244747)
Product No. : cs-1625
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 CCT244747 (CAS: 1404095-34-6) is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. 

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