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Products > PI3K/Akt/mTOR > ATM ATR > AZD-6738 (AZD6738, AZD 6738)
AZD-6738 (AZD6738, AZD 6738)
Product name : AZD-6738 (AZD6738, AZD 6738)
Product No. : cs-1601
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 AZD6738 (CAS: 1352226-88-0) is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. 

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