TGF-beta/Smad
PTEN
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Product name : AMG-319 (AMG319, AMG 319)
Product No. : cs-1593
Price : 100mg, $675, 500mg/$1875
CAS :
Bulk inquiry :
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| Details: |
AMG319 (CAS: 1608125-21-8) is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ with IC50 of 850 nM. AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death.
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