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Products > Stem cell signaling > Wnt > ETC-159 (ETC159, ETC 159)
ETC-159 (ETC159, ETC 159)
Product name : ETC-159 (ETC159, ETC 159)
Product No. : cs-1584
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 ETC-159 (CAS: 1638250-96-0) is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits β-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.  Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. 

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