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Products > JAK/STAT Signaling > JAK > NVP-BSK805 (BSK805, BSK 805, BSK-805)
NVP-BSK805 (BSK805, BSK 805, BSK-805)
Product name : NVP-BSK805 (BSK805, BSK 805, BSK-805)
Product No. : cs-1571
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 NVP-BSK805 (CAS: 1092499-93-8) is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba/F3 JAK2(V617F) cell-driven mouse mechanistic model. Furthermore, NVP-BSK805 potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats 

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