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Products > Protein Tyrosine Kinase/RTK > BTK > Acalabrutinib (ACP-196, ACP 196, ACP196)
Acalabrutinib (ACP-196, ACP 196, ACP196)
Product name : Acalabrutinib (ACP-196, ACP 196, ACP196)
Product No. : cs-1558
Price : 500mg, $975
CAS : 
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  Details:
  ACP-196 (CAS: 1420477-60-6) inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. 

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