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Products > Protein Tyrosine Kinase/RTK > FLT3 > SU5614 (SU-5614, SU 5614)
SU5614 (SU-5614, SU 5614)
Product name : SU5614 (SU-5614, SU 5614)
Product No. : cs-1552
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 SU5614 (CAS: 1055412-47-9) is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21. 

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