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Products > Immunology/Inflammation > Toll-like Receptor (TLR) > Motolimod (VTX-2337, VTX2337, VTX 2337, VTX-378, VTX378)
Motolimod (VTX-2337, VTX2337, VTX 2337, VTX-378, VTX378)
Product name : Motolimod (VTX-2337, VTX2337, VTX 2337, VTX-378, VTX378)
Product No. : cs-1536
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 Motolimod (CAS: 926927-61-9) is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system. 

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