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PX-478 (PX478, PX 478)
Product name : PX-478 (PX478, PX 478)
Product No. : cs-1467
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 PX-478 (CAS: 685898-44-6 (HCl salt); 685847-78-3 (free base) is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells. IF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis.

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