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Products > PI3K/Akt/mTOR > PI3K > GDC 0032 (Taselisib; RG-7604; GDC0032; GDC-0032)
GDC 0032 (Taselisib; RG-7604; GDC0032; GDC-0032)
Product name : GDC 0032 (Taselisib; RG-7604; GDC0032; GDC-0032)
Product No. : cs-1435
Price : 500mg, $975
CAS : 
Bulk inquiry : 
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  Details:
 GDC-0032 (CAS: 1282512-48-4) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ. GDC-0032 potently inhibits signal transduction downstream of PI3K and induces apoptosis at low concentrations in breast cancer cell lines and xenograft models that harbor PIK3CA mutations. 

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