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Products > PI3K/Akt/mTOR > PI3K > PI3065 (PI-3065)
PI3065 (PI-3065)
Product name : PI3065 (PI-3065)
Product No. : cs-1273
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
PI-3065 (CAS: 955977-50-1) is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. As p110δ is primarily expressed in leukocytes, drugs against p110δ have not been considered for the treatment of solid tumours. p110δ inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression. p110δ inhibitors can break tumour-induced immune tolerance and should be considered for wider use in oncology.


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