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Products > Protein Tyrosine Kinase/RTK > Bcr-Abl > RPI-1 (RPI1, RPI 1)
RPI-1 (RPI1, RPI 1)
Product name : RPI-1 (RPI1, RPI 1)
Product No. : cs-2266
Price : 100mg, $475, 500mg/$1275
CAS : 
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  Details:
RPI-1 (CAS: 269730-03-2) is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells.

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