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Products > Cell Cycle/DNA Damage > Mps1 > BAY1217389 (BAY 1217389; BAY-1217389)
BAY1217389 (BAY 1217389; BAY-1217389)
Product name : BAY1217389 (BAY 1217389; BAY-1217389)
Product No. : cs-2361
Price : 100mg, $675, 500mg/$1875
CAS : 
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  Details:
BAY 1217389 (CAS: 1554458-53-5) is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells.

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