TGF-beta/Smad
Metabolism
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Product name : HO-3867
Product No. : cs-2205
Price : 100mg, $475, 500mg/$1275
CAS :
Bulk inquiry :
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| Details: |
HO-3867 (CAS: 1172133-28-6)is a selective and potent STAT3 inhibitor. HO-3867 selectively inhibited STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 exhibited minimal toxicity toward noncancerous cells and tissues but induced apoptosis in ovarian cancer cells. Pharmacologic analysis revealed greater bioabsorption and bioavailability of the active (cytotoxic) metabolites in cancer cells compared with normal cells.
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