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Cariporide
Product name : Cariporide
Product No. : cs-1692
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
 The sodium-hydrogen exchanger isoform-1 (NHE-1) is the predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Cariporide (CAS: 159138-80-4) is a benzoylguanidine compound that inhibits NHE-1 with IC50 values ranging from 0.03-3.4 µM. It displays selectivity for NHE-1 over NHE-2, NHE-3, and NHE-5 (IC50s = 4.3-62, 1->100, and >30 µM, respectively).1 The cardioprotective efficacy of cariporide has been examined in clinical investigations of patients at risk for myocardial infarction

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