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Products > PI3K/Akt/mTOR > PI3K > AZD-8186 (AZD8186, AZD 8186)
AZD-8186 (AZD8186, AZD 8186)
Product name : AZD-8186 (AZD8186, AZD 8186)
Product No. : cs-1576
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 AZD8186 (CAS: 1627494-13-6) is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. 

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