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Products > Others > Others > OXi-4503
OXi-4503
Product name : OXi-4503
Product No. : cs-1521
Price : 100mg, $975, 500mg/$2475
CAS : 
Bulk inquiry : 
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  Details:
 OXi-4503 (CAS: 288847-34-7) is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. 

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