TGF-beta/Smad
EZH2
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Product name : NMS-873 (NMS873; NMS 873)
Product No. : cs-952
Price : 100mg, $675, 500mg/$1875
CAS :
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| Details: |
NMS-873 (CAS: 1418013-75-8) is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP). NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.
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