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Products > Protein Tyrosine Kinase/RTK > Src > WH-4-023 (Dual LCK/SRC inhibitor)
WH-4-023 (Dual LCK/SRC inhibitor)
Product name : WH-4-023 (Dual LCK/SRC inhibitor)
Product No. : cs-1827
Price : 100mg, $475, 500mg/$1275
CAS : 
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  Details:
 WH-4-023 (CAS: 837422-57-8) is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.  The lymphocyte-specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation.

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