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Products > Apoptosis > MDM-2, p53 > NVP-CGM097 ((CGM097; CGM 097; CGM-097; NVP CGM097)
NVP-CGM097 ((CGM097; CGM 097; CGM-097; NVP CGM097)
Product name : NVP-CGM097 ((CGM097; CGM 097; CGM-097; NVP CGM097)
Product No. : cs-1248
Price : 100mg, $975, 500mg/$2475
CAS : 
Bulk inquiry : 
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  Details:
CGM097 (CAS: 1313363-54-0) is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

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