TGF-beta/Smad
VEGFR
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Product name : Brigatinib (AP26113, AP-26113)
Product No. : cs-2153
Price : 200mg, $475, 500mg/$975
CAS :
Bulk inquiry :
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| Details: |
AP 26113 (CAS: 1197953-54-0) is a highly potent and selective investigational ALK inhibitor with mean IC50 value ＜ 100 nM in Ba/F3 cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.
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