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Products > Protein Tyrosine Kinase/RTK > ALK > PF-06463922 (PF06463922, Lorlatinib)
PF-06463922 (PF06463922, Lorlatinib)
Product name : PF-06463922 (PF06463922, Lorlatinib)
Product No. : cs-1727
Price : 100mg, $675, 500mg/$1475
CAS : 
Bulk inquiry : 
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  Details:
 PF-06463922 (CAS: 1454846-35-5) is a novel, orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. The kinase inhibition leads to disruption of ALK- and ROS1-mediated signaling and eventually inhibits tumor cell growth in ALK- and ROS1-overexpressing tumor cells.

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