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Products > Cell Cycle/DNA Damage > CDK > Roscovitine (CYC202; R-roscovitine; Seliciclib)
Roscovitine (CYC202; R-roscovitine; Seliciclib)
Product name : Roscovitine (CYC202; R-roscovitine; Seliciclib)
Product No. : cs-1845
Price : 500mg, $675
CAS : 
Bulk inquiry : 
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  Details:
 Roscovitine (CAS: 186692-46-6) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM; shows little effect on CDK4/6.  In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. 

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